Wine

To override Wine's default device mapping, run wine regedit and create string entries in HKEY_LOCAL_MACHINE\Software\Wine\Ports where the entry name is the Windows device name and the entry value is the path to the Unix device. Continuing with the above example, to make COM1 the first USB-attached serial port, create an entry with the name COM1 and the value /dev/ttyUSB0. You might also want to create an entry named COM5 with no value to remove the COM5 device which is now a duplicate of COM1. After editing the registry, shut down Wine with wineserver -k and the next time Wine runs a program, your changes will take effect.